aleung

Allen
Leung
Research Description: 

Although my research focuses and makes models for single cell organisms, perhaps the most incredible aspect of life is its ability for single-celled organisms to self-organize and differentiate to achieve a higher function. Specifically, in humans, we achieve this higher order function through autocrine, paracrine, and endocrine hormones. Hormones act on extracellular receptors to induce an intracellular response. The most notable of these enzymes within the context of metabolism and cell growth is epithelial growth factor (EGF) and its action in the MAPK signaling pathway. MAPK has significant feed-forward and feedback regulation with various other kinase signaling pathways but is closely tied to AMPK signaling as well. Due to its importance in various fields, especially oncology and developmental biology, models of MAPK are abundant. However, what the field lacks is accurate spatial reaction-diffusion networks. Elucidating the interplay between MAPK, AMPK, especially at low ATP concentrations is the eventual focus of my research.

Graduate Program: 
Nanoengineering
Department(s): 
Nanoengineering (Chem Eng)