The goal of our lab at the University of California, San Diego (called the Bio-Nano-Electronics or BioNE Lab) is to “Engineer nanoscale electronics for higher throughput cellular- and molecular-scale sensing, to accelerate scientific discoveries related to human health and disease”.  To design more intelligent nano-electronics we first carefully characterize the complex nano-bio interface. Next, we use this knowledge to design our nano-electronics to be higher throughput, accurate, sensitive, with minimal perturbations to the biological system. Finally, with confidence in our biological read-outs from these high-throughput tools, there is a need to develop algorithms that can “learn” from our big dataset to answer fundamental biological questions. In this seminar I will present our recent advances using the above approach to design a nanoscale platform for recording electrical signals in parallel from hundreds to thousands of cardiac cells for cardiotoxicity screening. I will also briefly discuss ongoing efforts in our lab to utilize our platform for neuronal and biofilm electrophysiology. 

The video of this presentation is available here.