
Jonathan Gunn
Bioengineering
Research Description
Jonathan Gunn is a second-year Bioengineering Ph.D. student in the combined M.D./Ph.D. program at UCSD. He earned his B.S. in Chemical Engineering and Mathematics from Johns Hopkins University, where he coauthored four publications, including a co-first author paper in Nature Biomedical Engineering detailing the Molecular Indexing of Proteins by Self-Assembly (MIPSA) technology. As an inventor of the MIPSA platform (Patent WO2022187277A1), Jonathan’s work laid the foundation for Infinity Bio, a startup led by his former mentors that has since profiled novel pathological autoantibodies implicated in autoimmune diseases in over ten thousand patients. Co-advised by Drs. Dan Kaufman and Ester Kwon, Jonathan is developing lipid nanoparticles for targeted delivery to T cells and Natural Killer (NK) cells for in vivo Chimeric Antigen Receptor (CAR) therapy. Furthermore, by utilizing self-amplifying RNA (saRNA), he aims to improve the long-term expression of the CAR protein, enhancing its potency and longevity. Outside of the lab, he has been active in UCSD’s Free Clinic, providing care to the uninsured, and has participated in Doc-4-A-Day to inspire high school students to pursue STEM careers. In his free time, Jonathan enjoys playing chess and tennis, as well as picnicking with his fiancée and dachshund at Kate Sessions Memorial Park.